Basic Biological Sciences
- 1 December 1981
- journal article
- research article
- Published by SAGE Publications in Journal of Dental Research
- Vol. 60 (12) , 1977-1982
- https://doi.org/10.1177/00220345810600120901
Abstract
The proliferation of bovine odontogenic epithelial (OE) and mesenchymal (OM) cells cultured in the presence of varying concentrations of epidermal growth factor (EGF) was examined. After a delay of two to three d, EGF-supplemented cultures contained significantly more cells than did controls. This effect was dose-dependent, was maximal at 10-9 g EGF/ml for OE and 10-8 g EGF/ml for OM, and was dependent on the presence of serum in the culture medium. The results suggest the possibility that EGF may play a role in the control of odontogenic cell proliferation in vivo.Keywords
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