A Last GASP for GPCRs?
- 26 July 2002
- journal article
- editorial
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 297 (5581) , 529-531
- https://doi.org/10.1126/science.1075453
Abstract
Once activated by their ligands, many G-protein-coupled receptors (GPCRs) are internalized into endocytic compartments within the cell. Here, they are sorted to either a recycling or a degradative pathway. In their Perspective, Gray and Roth discuss new work ( Whistler et al. ) that identifies a protein called GASP that is important for the lysosomal targeting of certain GPCRs.Keywords
This publication has 9 references indexed in Scilit:
- Modulation of Postendocytic Sorting of G Protein-Coupled ReceptorsScience, 2002
- Down-Regulation of Protease-activated Receptor-1 Is Regulated by Sorting Nexin 1Molecular Biology of the Cell, 2002
- Seven-transmembrane-spanning receptors and heart functionNature, 2002
- Agonist-promoted Ubiquitination of the G Protein-coupled Receptor CXCR4 Mediates Lysosomal SortingJournal of Biological Chemistry, 2001
- Regulation of Receptor Fate by Ubiquitination of Activated β 2 -Adrenergic Receptor and β-ArrestinScience, 2001
- Binding of the β2 Adrenergic Receptor toN-Ethylmaleimide-sensitive Factor Regulates Receptor RecyclingPublished by Elsevier ,2001
- The Cytoplasmic Tails of Protease-activated Receptor-1 and Substance P Receptor Specify Sorting to Lysosomes versusRecyclingJournal of Biological Chemistry, 1999
- G protein-coupled receptor (GPCR) trafficking in the central nervous system: relevance for drugs of abuseDrug and Alcohol Dependence, 1998
- Enhanced Degradation of EGF Receptors by a Sorting Nexin, SNX1Science, 1996