ALPHA‐1‐ANTITRYPSIN GLOBULES IN LIVER BIOPSIES

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Abstract
To examine the frequency of alpha-1-antitrypsin (AAT) deficiency of phenotype Pi-Z in a consecutive [human] liver biopsy material, PAS/diastase resistant globules with positive immunohistochemical reaction for AAT (AAT globules) were used as a marker of the Pi-Z gene; 34 (4%) of 850 liver biopsies contained AAT globules. More than half of the biopsies with globules had chief histological diagnoses within the groups fibrosis, suspicion of cirrhosis and cirrhosis. Micronodular cirrhosis was significantly more frequent in biopsies with AAT globules. The results support the assumption that AAT deficiency of phenotype Pi-Z in homozygous and heterozygous forms is associated with development of liver cirrhosis.

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