Nonlinear association between CGG repeat number and age of menopause in FMR1 premutation carriers
- 26 October 2005
- journal article
- research article
- Published by Springer Nature in European Journal of Human Genetics
- Vol. 14 (2) , 253-255
- https://doi.org/10.1038/sj.ejhg.5201510
Abstract
FMR1 premutations are known to be associated with premature ovarian failure (POF), but the underlying mechanism is unknown. We present evidence for a nonlinear association between menopause age and premutation size suggesting that premutations in the mid-size range are at greatest risk for POF, while larger premutations are at lower risk.Keywords
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