Inductions of Ornithine Decarboxylase and DNA Synthesis in Rat Stomach Mucosa by Formaldehyde
- 25 August 1988
- journal article
- research article
- Published by Wiley in Japanese Journal of Cancer Research
- Vol. 79 (8) , 917-920
- https://doi.org/10.1111/j.1349-7006.1988.tb00055.x
Abstract
Administration of formaldehyde at doses of 11 to 110 mg/kg body weight by gastric intubation to male F344 rats induced up to 100-fold increase in ornithine decarboxylase activity with a maximum after 16 hr and up to 49-fold increase in DNA synthesis with a maximum after 16 hr in the pyloric mucosa of the stomach. These results suggest that formaldehyde has tumor-promoting activity in carcinogenesis in the glandular stomach.Keywords
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