EFFECT OF THYROTROPIN ADMINISTRATION ON THEIN VITROUPTAKE AND CONVERSION OF I131AND RELEASE OF ORGANIC-BOUND I131BY THE ISOLATED THYROID GLAND

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Abstract
It was found that 3, 6 or 12 hours after thyroid stimulating hormone (TSH) administration to rats the isolated thyroid gland did not concentrate, convert and store I131 in vitro to the same degree as the gland from animals not injected with TSH. At 24 hours after TSH administration the thyroid seemed to have regained the capacity to take up, convert and store I131 to the same degree as the gland which was not stimulated by TSH. The decrease in the ability of the isolated thyroid gland, 3, 6 or 12 hours after TSH administration, to concentrate, convert and store I131 in vitro is interpreted as being caused by an increase in the blood thyroid hormone level produced by the exogenous TSH.