Distribution of glutamine and asparagine residues and their near neighbors in peptides and proteins.
- 15 October 1991
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 88 (20) , 8880-8884
- https://doi.org/10.1073/pnas.88.20.8880
Abstract
In a statistical study of neighboring residues in 1465 peptides and proteins comprising 450,431 residues, it was found that the preferences for residues neighboring to glutamine and asparagine residues are consistent with the hypothesis that the rates of deamidation of these residues are of biological significance. Some dipeptide and tripeptide structures have special usefulness and some are especially undesirable. More such structures exist for amide residues than for other residues, and their specific types are those most relevant to the deamidation of amide residues under biological conditions.Keywords
This publication has 9 references indexed in Scilit:
- Molecular clocks, molecular profiles, and optimum diets: Three approaches to the problem of agingPublished by Elsevier ,2003
- Deamidation, isomerization, and racemization at asparaginyl and aspartyl residues in peptides. Succinimide-linked reactions that contribute to protein degradation.Journal of Biological Chemistry, 1987
- Evolution and the Distribution of Glutaminyl and Asparaginyl Residues in ProteinsProceedings of the National Academy of Sciences, 1974
- SEQUENCE DEPENDENT DEAMIDATION RATES FOR MODEL PEPTIDES OF CYTOCHROME CInternational Journal of Peptide and Protein Research, 1974
- Deamidation of Glutaminyl and Asparaginyl Residues in Peptides and ProteinsCurrent Topics in Cellular Regulation, 1974
- Rates of nonenzymic deamidation of glutaminyl and asparaginyl residues in pentapeptidesJournal of the American Chemical Society, 1973
- Essential Chemical Requirements for Induction of Allergic EncephalomyelitisNature, 1971
- Controlled Deamidation of Peptides and Proteins: An Experimental Hazard and a Possible Biological TimerProceedings of the National Academy of Sciences, 1970
- MULTIPLE FORMS OF CYTOCHROME C IN RAT - PRECURSOR-PRODUCT RELATIONSHIP BETWEEN MAIN COMPONENT CY I AND MINOR COMPONENTS CY 2 AND CY 3 IN VIVO1968