Defective Phagocytosis in Anaplasma phagocytophilum - Infected Neutrophils
Open Access
- 1 February 2005
- journal article
- research article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 73 (2) , 1187-1190
- https://doi.org/10.1128/iai.73.2.1187-1190.2005
Abstract
Anaplasma phagocytophilum infection induces functional neutrophil changes. Using both Candida albicans and fluorescent-aggregate phagocytosis assays, we examined whether neutrophil and dimethyl sulfoxide-differentiated HL-60 cell infection impairs internalization. A. phagocytophilum infection significantly decreased phagocytosis compared to that of controls ( P < 0.05). This further impairment of neutrophil function may promote opportunistic infections and exacerbate disease.Keywords
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