Comparison between rush immunotherapy with a standardized allergen and an alum adjuved pyridine extracted material in grass pollen allergy

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Abstract
Rush immunotherapy with a standardized and lyophilized cocksfoot pollen extract was performed in 23 allergic subjects and compared with classical immunotherapy done with an alum-adjuved, pyridine-extracted cockfoot pollen extract (15 subjects) and a control group of 10 patients. The 3 groups were perfectly matched. Clinical benefits were analyzed by symptom scores. Rush immunotherapy gave significantly better results when asthma or rhinitis was considered than either classical immunotherapy (P < 0.02) or in the control group (P < 0.01 and 0.02). Skin tests were significantly reduced after rush immunotherapy and did not change in the 2 other groups. After the pollen season the skin test reactivity was increased in the rush immunotherapy group. Cocksfoot pollen-specific IgE did not vary significantly in the 3 groups. Cocksfoot pollen specific-IgG was significantly (P < 0.05) increased in the rush immunotherapy group before the pollen season and did not vary significantly in the other groups.