Species specific grass pollen sensitivity: diagnosis and treatment with single grass species Allpyral vaccines

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Abstract
Skin test titrations and nasal provocation tests in 60 patients with hay fever showed specific reactions to extracts of individual grass species. There was no correlation between skin and nasal sensitivity. Repeat testing after treatment with Allpyral vaccines consisting of the grass species to which the nasal reaction was most severe, or only 1 of several pollens to which reactions were equally severe, showed marked diminution of skin and nasal sensitivity not only to the single pollen used for immuno-therapy but to all 5 common pollens used in the Allpyral grass mix. Clinical results seemed much improved compared with results in the same year for Allpyral 5 grass mix vaccines, especially in the case of patients treated with Timothy, rye, or cocksfoot. These 3 grasses were to be preferred for treatment in England, and these grasses contain common allergens.