A clinical trial comparing sustained release amitriptyline (Saroten® Retard) and conventional amitriptyline tablets (Saroten®) in endogenously depressed patients with simultaneous determination of serum levels of amitriptyline and nortriptyline

Publisher Website
Google Scholar
Abstract
The clinical effect of a sustained release preparation of amitriptyline was compared with that of conventional amitriptyline tablets in a double-blind cross-over study with 24 patients suffering from endogenous depression. The sustained release preparation was given in a single evening dose of 2/3 the total daily dose of conventional tablets, which was given in a 3 times a day regimen. Serum concentrations of amitriptyline and its active metabolite, nontriptyline, were determined. No difference was found between the 2 preparations as regards either clinical effect or side effects. No correlation could be shown between the clinical effects and the serum concentrations of amitriptyline and nortriptyline.