Prophylaxis of Isoniazid Neuropathy with Pyridoxine

Publisher Website
Google Scholar
Abstract
SHORTLY after the introduction of isoniazid in 1952, Pegum1 described a patient who after a week of therapy with this drug complained of "burning feet"; he suggested that induced nicotinic acid deficiency might be the cause. Later, McConnell and Cheetham2 reported a case of "acute pellagra" complicating therapy with isoniazid that responded to nicotinic acid and a preparation containing vitamin B complex. In 1953 Jones and Jones3 presented 2 cases of peripheral neuropathy in isoniazid-treated patients; 1 of these had signs of pellagra that responded to nicotinamide, after failing to improve on thiamine. These authors also suggested that pyridoxine (vitamin . . .