Persistence of Neuroadapted Mumps Virus in Brains of Newborn Hamsters after Intraperitoneal Inoculation

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Abstract
Neuroadapted mumps virus produces systemic infection in newborn hamsters after intraperitoneal inoculation. Virus is disseminated via a low-level viremia and appears to enter the central nervous system by passage through the choroid plexus. At such sites, choroidal and ependymal epithelial cells are productively infected and become a source for further viral spread throughout the brain parenchyma. The development of neutralizing and hemagglutination-inhibiting antibodies in serum correlates with the clearance of virus from most systemic sites. However, persistence of virus in both brain and kidney is demonstrated late in this infection.

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