EFFECT OF LTD4 ON CONJUNCTIVAL VASOPERMEABILITY AND BLOOD AQUEOUS BARRIER INTEGRITY

  • 1 January 1985
    • journal article
    • research article
    • Vol. 26  (4) , 481-485
Abstract
The effect of leukotriene D4 (LTD4) on the microvascular permeability of selected ocular tissues of the guinea pig was evaluated quantitatively by utilizing 125I-albumin and 51Cr-erythrocytes. Topically applied LTD4 (1 ng-10 .mu.g) produced a dose-related increase in conjunctival microvascular permeability. However, topical administration of such doses of LTD4 did not promote albumin leakage into the aqueous humor or iris-ciliary body. Intravitreal injection of graded doses of LTD4 also failed to increase the albumin content of the aqueous humor and iris-ciliary body. Although LTD4 increased conjunctival microvascular permeability, it does not appear to disrupt the blood-aqueous barrier of the guinea pig eye.