Genetic Response of Inbred Lines of Chickens to Rous Sarcoma Virus

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Abstract
This study demonstrates the genetic variation among families of White Leghorn chickens, representing 5 different and unrelated inbred lines, when they were inoculated intracerebrally at 1 day of age with Rous sarcoma virus. The differences in response to inoculation of chickens with Rous sarcoma virus, both within and between lines, were marked. The progeny from line 10 representing 4 different sire matings, each mated to different groups of females, were completely susceptible and all died from the effects of the disease induced by inoculation. In contrast the progeny from line 7, representing 3 different sire matings, were highly resistant and only 2 chickens of 327 died. Progeny from lines 6, 9, and 15 showed considerable genetic diversity in response to Rous sarcoma virus. Within lines the progeny from certain males showed considerable resistance, while the progeny of other males in these same lines all died before 25 days of age. Likewise, progeny from dams, within sires and lines, showed similar genetic diversity in response to Rous sarcoma virus, some being completely resistant and others completely susceptible.