In Vitro Pharmacodynamic Properties of Three Antifungal Agents against PreformedCandida albicansBiofilms Determined by Time-Kill Studies
- 1 November 2002
- journal article
- research article
- Published by American Society for Microbiology in Antimicrobial Agents and Chemotherapy
- Vol. 46 (11) , 3634-6
- https://doi.org/10.1128/aac.46.11.3634-3636.2002
Abstract
We have examined the in vitro activities of fluconazole, amphotericin B, and caspofungin against Candida albicans biofilms by time-kill methodology. Fluconazole was ineffective against biofilms. Killing of biofilm cells was suboptimal at therapeutic concentrations of amphotericin B. Caspofungin displayed the most effective pharmacokinetic properties, with > or =99% killing at physiological concentrations.Keywords
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