Getting to the guts of enteroendocrine differentiation
- 1 January 2000
- journal article
- editorial
- Published by Springer Nature in Nature Genetics
- Vol. 24 (1) , 3-4
- https://doi.org/10.1038/71653
Abstract
The endodermal epithelium of vertebrates generates many types of enteroendocrine cells, including the insulin- and glucagon-secreting cells of the islets of Langerhans. Two studies disclose that Notch signalling controls which cells differentiate as enteroendocrine cells—a finding with implications for therapeutic strategy.Keywords
This publication has 13 references indexed in Scilit:
- Control of endodermal endocrine development by Hes-1Nature Genetics, 2000
- Pancreas: how to get there from the gut?Current Opinion in Cell Biology, 1999
- Notch signalling controls pancreatic cell differentiationNature, 1999
- The New Biology of Gastrointestinal HormonesPhysiological Reviews, 1998
- Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/NeuroD-deficient miceGenes & Development, 1997
- Pax6 is required for differentiation of glucagon-producing α-cells in mouse pancreasNature, 1997
- Neurogenic genes and vertebrate neurogenesisCurrent Opinion in Neurobiology, 1996
- Primary neurogenesis in Xenopus embryos regulated by a homologue of the Drosophila neurogenic gene DeltaNature, 1995
- Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine III. Entero‐endocrine cellsJournal of Anatomy, 1974
- THE CYTOCHEMISTRY AND ULTRASTRUCTURE OF POLYPEPTIDE HORMONE-PRODUCING CELLS OF THE APUD SERIES AND THE EMBRYOLOGIC, PHYSIOLOGIC AND PATHOLOGIC IMPLICATIONS OF THE CONCEPTJournal of Histochemistry & Cytochemistry, 1969