Functional simian virus 40 T antigen is expressed in hybrid cells having finite proliferative potential.
Open Access
- 1 April 1987
- journal article
- research article
- Published by Taylor & Francis in Molecular and Cellular Biology
- Vol. 7 (4) , 1541-1544
- https://doi.org/10.1128/mcb.7.4.1541
Abstract
Simian virus 40-transformed human cells fused with other independently derived simian virus 40-transformed cells and tumor-derived cells containing activated H-ras and N-ras oncogenes yielded hybrids capable of indefinite division. Fusions with various other immortal cells yielded hybrids that had limited division potential. T antigen expressed in limited-division hybrids was functional for the induction of cellular DNA synthesis.This publication has 30 references indexed in Scilit:
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