Alkaline phosphatase positive precursors of adipocytes in the human bone marrow

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Abstract
Summary Developing fat cells in the bone marrow of leukaemic patients treated with chemotherapy were found to be endowed with membrane-bound alkaline phosphatase. Since alkaline phosphatase is a cytochemical marker of ‘reticular’cells, this observation provides cytochemical evidence that reticular cells may convert to adipocytes when marrow cellularity abruptly decreases.