Establishment of a human oligodendroglial cell line
- 1 January 1979
- journal article
- research article
- Published by Springer Nature in Acta Neuropathologica
- Vol. 46 (1-2) , 51-55
- https://doi.org/10.1007/bf00684804
Abstract
A human oligodendroglial cell line has been established from a mixed glioma. Over a period of 22 months, the cell consisted of cells with the morphologic features of such a strong perinuclear halo, dichotomous branching, and a tendency to aggregate and float in the medium. In small aggregates, most cells are bipolar. The cell line also continues to synthetize the S-100 protein specific to neural tissue. The response of this cell line to dibutyryl-cyclic AMP is striking, resulting in a remarkable narrowing and elongation of the cell processes. This cell line could be used for studies on glial differentiation and neuron-glia interaction.This publication has 23 references indexed in Scilit:
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