HLA Antigens in Two Siblings with Autoimmune Addison's Disease

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Abstract
The diagnosis of autoimmune Addison''s disease was established in 2 siblings by demonstration of serum antibodies against adrenal cortex antigen, elevated P-ACTH combined with a low P-cortisol, and the absence of P-cortisol response to exogenous ACTH. HLA typing in the 2 siblings and their parents revealed the same HLA phenotype in the 2 patients. This is compatible with an autosomal recessive mode of inheritance and indicates a supposed trait for autoimmune Addison''s disease may segregate with the HLA complex in the familial form of autoimmune Addison''s disease.