Comparison between bacampicillin and amoxycillin in treating genital and extragenital infection with Neisseria gonorrhoeae and pharyngeal infection with Neisseria meningitidis.

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Abstract
Sixty-three patients presumed to have genital gonorrhea who gave histories of extragenital sexual practices were randomly treated with amoxycillin 3 g or bacampicillin 4.8 g (equivalent to 3.5 g ampicillin) with probenecid 1 g to compare the efficacy of the drugs in treating gonorrhea at all sites. Three patients were initially culture negative, and 7 failed to return for follow-up. Twenty-seven of 28 patients receiving bacampicillin and all 25 receiving amoxycillin gave negative genital cultures for N. gonorrhoeae 5-9 days after treatment. Twenty-two of 60 patients had extragenital gonorrhea. One failed to return, but all 8 who had received amoxycillin and 12 of 13 who had received bacampicillin gave negative pharyngeal and anorectal cultures after treatment. N. meningitidis was isolated from the pharynx in 17 of 60 patients on initial attendance. Three of 14 were still colonized with the meningococcus after treatment. Two of 32 patients receiving amoxycillin and 12 of 31 receiving bacampicillin reported experiencing gastrointestinal side-effects.

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