Control of Proteolytic Activity in Serum: Effect of Soybean Inhibitor in Vivo in the Mouse
- 1 August 1951
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 166 (2) , 485-491
- https://doi.org/10.1152/ajplegacy.1951.166.2.485
Abstract
Soybean inhibitor (SBI) was injected by tail vein into mice of the A strain in single doses of 2.5 to 40 mg. A significant elevation of antiproteolytic titer and decrease in proteolytic activity of the sera was observed in those mice receiving more than 24 mg. of SBI. Significant elevation of the APL titer remained after 7 days. Serial injns. of 20 mg. weekly for 6 wks. resulted in no demonstrable abnormalities in the animals as indicated by observation during life or by post-morten gross and microscopic examination of their organs.Keywords
This publication has 2 references indexed in Scilit:
- Use of Antitryptic Agents in Tissue Culture. I. Crude Soybean Trypsin-Inhibitor.Experimental Biology and Medicine, 1949
- Fibrinogenolytic Demonstration of Activation and Inhibition of Tryptase in Plasma Protein Fraction-I ("Antihemophilic Globulin").Experimental Biology and Medicine, 1947