Social interaction-mediated lifespan extension of Drosophila Cu/Zn superoxide dismutase mutants
- 27 May 2008
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 105 (21) , 7506-7510
- https://doi.org/10.1073/pnas.0711127105
Abstract
Beneficial effects of social interaction on aging have been studied in humans and other species. We found that short-lived Drosophila mutants of the antioxidant enzyme Cu/Zn superoxide dismutase displayed a robust lifespan extension, with improved stress resistance and motor ability, upon cohousing with active flies of longer lifespan or younger age. Genetic, surgical, and environmental manipulations revealed motor and sensory components in behavioral interactions required for the lifespan extension induced by cohousing. Our results provide a definitive case of beneficial social interaction on lifespan and a useful entry point for analyzing the underlying molecular networks and physiological mechanisms.Keywords
This publication has 28 references indexed in Scilit:
- The Influence of Social Hierarchy on Primate HealthScience, 2005
- Social experience and pheromonal perception can change male–male interactions inDrosophila melanogasterJournal of Experimental Biology, 2005
- Two Interdependent TRPV Channel Subunits, Inactive and Nanchung, Mediate Hearing inDrosophilaJournal of Neuroscience, 2004
- Epigenetic Regulation of Aging in Honeybee WorkersScience of Aging Knowledge Environment, 2004
- Fighting fruit flies: A model system for the study of aggressionProceedings of the National Academy of Sciences, 2002
- Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate ProteinScience, 2001
- OXYTOCIN MAY MEDIATE THE BENEFITS OF POSITIVE SOCIAL INTERACTION AND EMOTIONS1The purpose of this paper is to describe the neuroendocrine mechanisms of positive social interactions.1Psychoneuroendocrinology, 1998
- Development and maintenance of a simple reflex circuit in small‐patch mosaics of Drosophila: Effects of altered neuronal function and developmental arrestJournal of Neurobiology, 1993
- Cloning, sequence analysis and chromosomal localization of the Cu-Zn Superoxide dismutase gene of Drosophila melanogasterGene, 1989
- The effects on locomotor activity and reactivity of the hypoactive and inactive mutations of Drosophila melanogasterHeredity, 1988