Free Radical Dna Adduct 8-Oh-Deoxyguanosine Affects Activity of Hp a II and Msp I Restriction Endonucleases

Abstract
8-OH-deoxyguanosine can diminish the ability of the restriction endonucleases Hpa II and Msp I to cleave DNA. The exact position of the adduct within the recognition site appears to determine the extent of the effect.