Inducible Nitric Oxide Synthase Binds, S-Nitrosylates, and Activates Cyclooxygenase-2
Top Cited Papers
- 23 December 2005
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 310 (5756) , 1966-1970
- https://doi.org/10.1126/science.1119407
Abstract
Cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) are two major inflammatory mediators. Here we show that iNOS specifically binds to COX-2 and S-nitrosylates it, enhancing COX-2 catalytic activity. Selectively disrupting iNOS–COX-2 binding prevented NO-mediated activation of COX-2. This synergistic molecular interaction between two inflammatory systems may inform the development of anti-inflammatory drugs.Keywords
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