Variation in the Structure of Varicella-Zoster Virus DNA
- 31 December 1983
- journal article
- research article
- Published by S. Karger AG in Intervirology
- Vol. 21 (1) , 25-37
- https://doi.org/10.1159/000149500
Abstract
By analyzing the fine structure of varicella-zoster virus (VZV) DNA, a naturally occurring heterogeneity was found on the right end of VZV DNA, but no evidence of a true terminal repetition was uncovered. We were unable to confirm the report of Straus and co-workers (1981) that there is a relatively high frequency of circular VZV DNA in low-passage virus. On long-term cell passage, extensive heterogeneity appeared concomitant with the accumulation of apparently defective VZV DNA.Keywords
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