Elimination of the Sarcoma Genome from Murine Sarcoma Virus Transformed Cat Cells
- 26 March 1976
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 191 (4233) , 1264-1266
- https://doi.org/10.1126/science.1257745
Abstract
Cat cells transformed by Moloney murine sarcoma virus contain virus-specific sequences in their RNA and DNA. Cloned, spontaneous revertant cell lines derived from clones of these cells had no evidence of the sarcoma genome in the cell RNA or DNA as judged by RNA-complementary DNA or DNA-complementary DNA hybridizations. This is apparently the first report of loss of a transforming genome in a revertant cell line.This publication has 16 references indexed in Scilit:
- The persistence and expression of virus-specific DNA in revertants of Rous sarcoma virus-transformed BHK-21 cellsVirology, 1974
- Molecular Relatedness of Mammalian RNA Tumor Viruses as Determined by DNA ⋅ RNA HybridizationScience, 1973
- RNA-directed DNA synthesis by virions of Rous sarcoma virus: Further characterization of the templates and the extent of their transcriptionVirology, 1973
- Reversion of Murine Sarcoma Virus Transformed Mouse Cells: Variants without a Rescuable Sarcoma VirusScience, 1972
- CONTACT-INHIBITED REVERTANT CELL LINES ISOLATED FROM SV40-TRANSFORMED CELLSThe Journal of cell biology, 1971
- Isolation of murine sarcoma virus‐transormed mouse cells which are negative for leukemia virus from agar suspension culturesInternational Journal of Cancer, 1970
- Reversion of Properties in Cells transformed by Polyoma VirusNature, 1968
- Repeated Sequences in DNAScience, 1968
- A nuclease specific for heat-denatured DNA isolated from a product of Aspergillus oryzaeBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1966
- Reversion in Hamster Cells Transformed by Rous Sarcoma VirusScience, 1965