Five new mouse susceptibility to colon cancer loci, Scc11–Scc15

16 October 2003

journal article
Published by Springer Nature in Oncogene

Vol. 22 (46) , 7258-7260
https://doi.org/10.1038/sj.onc.1207096

Abstract

Although several genes causing familial cancer syndromes have been identified, susceptibility to sporadic cancer remains unsolved. Animal experiments have demonstrated a large number of quantitative trait loci affecting cancer susceptibility. Previously, we described in mouse strain CcS-19/Dem five susceptibility to colon cancer (Scc) loci, Scc1-Scc5 controlling tumor numbers. In the present study, we performed an independent identical mouse cross using a distinct carcinogen, azoxymethane, to induce colon tumors. We confirmed all five originally described Scc loci and detected five additional new Scc loci; Scc11-Scc15. All these loci were detected in two-way interactions.

Keywords

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