Serum Lipid and Protein Fractions

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Abstract
Lipoprotein content of serum was measured by comparing electrophoretic patterns of the proteins before and after cold ether extraction (McFarlane Method) using barbiturate buffer pH 8.6. Sera studied consisted of 32 patients with arteriosclerosis obliterans, 7 with myocardial infarction, 28 with thromboangiitis obliterans, 4 with hypothyroidism, 3 with angina pectoris, 10 with hypertensive cardiovascular disease, 12 with primary essential xanthomatosis. Some of these patients were observed up to 3.5 years. Normal professional personnel were used as controls and also compared were some 39 professional blood donors. The most significant decrease in albumin was in primary essential xanthomatosis. The alpha 1 globulin remained practically constant. The alpha 2 globulin was slightly increased in these cases but most in shock. The beta globulin was increased most in primary essential xanthomatosis, although increased in all diseases where lipids are increased. Slight increase present in thromboangiitis obliterans even with normal lipids. Gamma globulin slightly increased in hypertensives. About 50% of patients with arteriosclerosis obliterans had normal serum lipid levels. The professional blood donor had less albumin and more globulin than the non-donor used as a control.