Spiramycin Excretion in Animals : III. A Single Oral Dose in Dogs

Abstract
Spiramycin concentrations were determined in plasma and parotid and sublingual fluids of unanesthetized dogs 1 to 6 and 24 hours after a single oral dose of the antibiotic. Plasma levels were highest 1 to 4 hours after dosage. Sustained sublingual secretion and peak parotid levels of spiramycin occurred at later collection times.