HUMAN RENAL ORGANIC ANION TRANSPORTER 1 (hOAT1) AND ITS ROLE IN THE NEPHROTOXICITY OF ANTIVIRAL NUCLEOTIDE ANALOGS
- 31 March 2001
- journal article
- Published by Taylor & Francis in Nucleosides, Nucleotides and Nucleic Acids
- Vol. 20 (4-7) , 641-648
- https://doi.org/10.1081/ncn-100002341
Abstract
HOAT1 is a renal membrane protein able to efficiently transport acyclic nucleoside phosphonates (ANPs). When expressed in CHO cells, hOAT1 mediates the uptake and cytotoxicity of ANPs suggesting that it plays an active role in the nephrotoxicity associated with cidofovir CMV therapy and high-dose adefovir HIV therapy. Although efficiently transported by hOAT1, tenofovir did not show any significant cytotoxicity in isolated human proximal tubular cells, which correlates with the lack of nephrotoxicity observed in HIV-infected patients on prolonged tenofovir therapy.Keywords
This publication has 19 references indexed in Scilit:
- Adefovir dipivoxil for the treatment of lamivudine-resistant hepatitis B mutantsHepatology, 2000
- Cidofovir, a new approach for the treatment of cervix intraepithelial neoplasia grade III (CIN III)Journal of Medical Virology, 2000
- Efficacy and Safety of Adefovir Dipivoxil With Antiretroviral TherapyA Randomized Controlled TrialJAMA, 1999
- The Antiviral Nucleotide Analogs Cidofovir and Adefovir Are Novel Substrates for Human and Rat Renal Organic Anion Transporter 1Molecular Pharmacology, 1999
- Remission of AIDS-associated progressive multifocal leukoencephalopathy after cidofovir therapyZeitschrift für Neurologie, 1999
- Clinical Pharmacokinetics of the Antiviral Nucleotide Analogues Cidofovir and AdefovirClinical Pharmacokinetics, 1999
- Effect of Oral Probenecid Coadministration on the Chronic Toxicity and Pharmacokinetics of Intravenous Cidofovir in Cynomolgus MonkeysToxicological Sciences, 1998
- Treatment of severe laryngeal papillomatosis with intralesional injections of cidofovir [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine]Journal of Medical Virology, 1998
- Intravenous Cidofovir for Peripheral Cytomegalovirus Retinitis in Patients with AIDSAnnals of Internal Medicine, 1997
- 1-[((S)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl] cytosine, an intracellular prodrug for (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine with improved therapeutic index in vivoAntimicrobial Agents and Chemotherapy, 1994