INDUCTION OF DIGESTIVE-TRACT TUMORS AND LEUKEMIAS IN DONRYU RATS BY ADMINISTRATION OF 1-AMYL-1-NITROSOUREA IN DRINKING-WATER
- 1 January 1980
- journal article
- research article
- Vol. 71 (4) , 464-470
Abstract
The effects of administration of 1-amyl-1-nitrosourea (ANU) at doses of 400, 200, 100 and 0 ppm in the drinking water to Donryu rats of both sexes were studied. Tumors developed in 166/205 (81%) rats that received ANU, as compared with 9/34 (27%) control rats. The incidence of digestive tract tumors was highest (76%), followed by hematopoietic tissue (11%) and liver (9%) tumors. In females, mammary tumors were also found. There appeared to be a dose-response relationship among the 3 treated groups as regards the incidence of tumors of the hematopoietic tissues and the average survival time.This publication has 3 references indexed in Scilit:
- Induction of Duodenal Tumors in F344 Rats by Continuous Oral Administration of N-Ethyl-N-nitrosourea2JNCI Journal of the National Cancer Institute, 1980
- Mammary tumorigenic effect of a new nitrosourea, 1,3-dibutyl-l-nitrosourea (B-BNU), in female Donryu ratsZeitschrift für Krebsforschung und Klinische Onkologie, 1980
- Leukemias and Vaginal Tumors Induced in Female Donryu Rats by Continuous Administration of l-Butyl-3,3-dimethyl-l-nitrosourea in the Drinking Water2JNCI Journal of the National Cancer Institute, 1976