Compatibility of Ibuprofen and Ethenzamide

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Abstract
The compatibility of ibuprofen and various drugs was investigated by thermal analysis. The results showed a lower melting point with many drugs. The compound of ibuprofen and ethenzamide was selected for detailed compatibility investigation. First, a ratio composition of a eutectic of ibuprofen and ethenzamide was estimated. A ratio composition of a eutectic of ibuprofen and ethenzamide of weight ratio 3:2 was suggested, and its melting point was approximately 56°C. Further, we investigated crystallization by powder x-ray diffraction. The resulting powder x-ray diffraction pattern of the compound that was heat treated was almost the same as that of the physical mixture, indicating that the crystallinity of ibuprofen and ethenzamide were not affected by the heat treatment. Next, we investigated the chemical stability of ibuprofen, ethenzamide, and a small amount of various excipients in capsule form, stored under conditions of 65°, 50°, and 40°C. It was established that ibuprofen and ethenzamide are stable. However, it was found that there is a remarkable delay of dissolution speed under conditions above 50°C.

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