Synthesis of Acyclonucleoside Phosphonates as Antiviral Agents Against Cytomegalovirus
- 1 March 1994
- journal article
- research article
- Published by Taylor & Francis in Nucleosides and Nucleotides
- Vol. 13 (1-3) , 539-550
- https://doi.org/10.1080/15257779408013261
Abstract
Phosphonic acid analogs of ACV and DHPG that are isosteric with ACV phosphate and DHPG phosphate have been synthesized and evaluated for antiviral activity against human, murine, and guinea pig strains of cytomegalovirus. The phosphonates showed high activity against all of the strains. They were also evaluated against a DHPG resistant strain of human cytomegalovirus. Although the activity dropped considerably, significant antiviral activity was still evident.Keywords
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