Role of Selenium in Protection against Lead Intoxication

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Abstract
The administration of Se concomitantly with Pb in rats restrained the Pb induced enzymuria, proteinuria, enhanced urinary excretion of .delta.-aminolevulinic acid, inhibition of the activities of certain renal enzymes, blood .delta.-aminolevulinic acid dehydratase and blood, liver and kidney uptake of Pb. The protective effect of Se against Pb toxicity may be attributed to a competition between Se and Pb for binding with the functional bioligands or to the in vivo formation of lead selenide.