Glucose and Lactate Concentrations in Plasma of Chickens with Myeloblastosis and Erythroblastosis23

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Abstract
Studies on the glucose and lactate concentrations in plasma of normal chickens and of chickens with myeloblastosis and erythroblastosis are described. The glucose level in the normal birds was 13.0 ± 1.9 µmoles per ml. and that of lactate was 6.7 ± 1.2 µmoles per ml. In chickens with either leukemia, the glucose concentration was maintained until about 24 hours before death when there was a rapid and profound decline to levels in the recorded range of 0.64 µmoles per ml. in erythroblastosis and 2.9 µmoles per ml. in myeloblastosis. As the diseases progressed, plasma lactate rose to levels 2 to 3 times the normal values. These changes in myeloblastosis were proportional to the volumes of packed primitive cells from the circulation but were not proportional in erythroblastosis. Thus, it seems probable that the decline in plasma glucose and the increase in lactate were related primarily to the disease in the total host rather than to specific activity of the circulating cells.