Voltammetric Behaviour of CRE-319, A Novel Dihydropyridine Calcium Antagonist and Its Polarographic, UV Spectrophotometric and HPLC Determination
- 1 December 1992
- journal article
- pharmaceutical analysis
- Published by Taylor & Francis in Analytical Letters
- Vol. 25 (12) , 2225-2237
- https://doi.org/10.1080/00032719208017958
Abstract
CRE-319, a novel 1, 4-dihydropyridine derivative, produces a cathodic polarographic peak due to the reduction of its nitro group according to the following well-known general pathway for the nitro group: The electrode mechanism is strongly dependent on the pH of the solution and follows a similar behaviour to that previously reported for nitrobenzene. The peak current shows a linear dependence with CRE-319 concentrations. This behaviour is used for analytical purposes in determining CRE-319 content in solution. In order to obtain comparative results, we have also developed a spectrophotomebic and an HPLC method for quantifying CRE-3 19.Keywords
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