BIOCHEMICAL STUDIES IN MULTIPLE SCLEROSIS

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Abstract
Blood and urinary excretion changes after the oral admn. of glucose, 1.25 g./kg. body wt., were studied in 50 multiple sclerosis patients and 30 healthy controls. Zero and hourly blood and urine samples were collected for 4 hrs. Each blood sample was analyzed for glucose, lactic acid and pyruvic acid; serum for K, Na, Ca, inorg. PO4, Mg, proteins, true and total cholinesterase and cholesterol. Urine samples were analyzed for total N, uric acid, creatine and creatinine, Na, K, Cl, and inorg. PO4. In multiple sclerosis, both in relapse and remission, the ratio pyruvic acid/lactic acid is higher than in the controls. Serum cholesterol was elevated. Serum inorg. PO4 was lower. The excretion of inorg. PO4/creatinine increased after glucose in the multiple sclerosis patients as compared to a decreased excretion in the controls. The excretion of uric acid/creatinine after glucose was lower than normal in the patients in relapse. These results, along with those of the other determinations, are discussed. Under glucose stress the biochemical pattern in multiple sclerosis was found to be distinctive and of diagnostic importance.