Electrochemistry of Anticonvulsants: Electron Transfer as a Possible Mode of Action
- 1 September 1992
- Vol. 33 (5) , 936-943
- https://doi.org/10.1111/j.1528-1157.1992.tb02204.x
Abstract
Reduction potentials were determined for various anticonvulsants, including progabide, SL 75.102, CGS 9896, pyridazines, zonisamide, 1,2,3-triazoles, and copper complexes. The values generally were in the range of about -0.1 to -0.6 V for the protonated drugs and the metal complexes. Reduction potentials provide information on the feasibility of electron transfer (ET) in vivo. If the value is relatively positive (greater than about -0.6 V), the agent can act catalytically as an electron acceptor from an appropriate cellular donor. A concomitant favorable influence on abnormal neuronal processes associated with epilepsy could occur. We describe ET as a possible mode of action of anticonvulsants as well as some antiepileptic agents with no electrochemical data based on this hypothetical ET approach.Keywords
This publication has 37 references indexed in Scilit:
- Theoretical Studies on Mechanism of Mptp Action: Et Interference by Mpp+(1-Methyl-4-Phenylpyridinium) With Mitochondrial Respiration vs. Oxidative StressFree Radical Research Communications, 1991
- Theoretical calculations on calcium channel drugs: Is electron transfer involved mechanistically?Chemico-Biological Interactions, 1990
- Reduction potentials of antimycobacterial agents: Relationship to activityBioelectrochemistry and Bioenergetics, 1989
- Potential anticonvulsant. XII. Anticonvulsant activity of some aldehyde derivativesEuropean Journal of Medicinal Chemistry, 1989
- Model study on the bioreduction of paraquat, MPP+, and analogs. Evidence against a “redox cycling” mechanism in MPTP neurotoxicityBiochemical and Biophysical Research Communications, 1987
- Charge transfer mechanism for benzodiazepine (BZ) actionBioelectrochemistry and Bioenergetics, 1986
- Conjugated and cross-conjugated mesomeric betaines. correlation of electroreduction with structure and physiological activityLife Sciences, 1986
- Tumor-promoting activity of benzodiazepine tranquilizers, diazepam and oxazepam, in mouse liverCarcinogenesis: Integrative Cancer Research, 1986
- Charge transfer and oxy radicals in antimalarial action. Quinones, dapsone metabolites, metal complexes, imunium ions, and peroxidesJournal of Free Radicals in Biology & Medicine, 1985
- The Reduction Potentials of Various NaphthoquinonesJournal of the American Chemical Society, 1935