Model study on the bioreduction of paraquat, MPP+, and analogs. Evidence against a “redox cycling” mechanism in MPTP neurotoxicity
- 31 August 1987
- journal article
- research article
- Published by Elsevier in Biochemical and Biophysical Research Communications
- Vol. 147 (3) , 1095-1104
- https://doi.org/10.1016/s0006-291x(87)80183-3
Abstract
No abstract availableKeywords
This publication has 63 references indexed in Scilit:
- Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidasePublished by Elsevier ,2004
- 1-Methyl-4-phenylpyridinium (MPP+) but not 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) selectively destroys dopaminergic neurons in cultures of dissociated rat mesencephalic neuronsNeuroscience Letters, 1986
- The pharmacology of the parkinsonian syndrome producing neurotoxin MPTP (1–methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine) and structurally related compoundsMedicinal Research Reviews, 1986
- 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridine (MPP+) cause rapid ATP depletion in isolated hepatocytesBiochemical and Biophysical Research Communications, 1986
- Comparative toxicity of MPTP, MPP+ and 3,3-dimethyl-MPDP+ to dopaminergic neurons of the rat substantia nigraEuropean Journal of Pharmacology, 1986
- 1-Methyl-4-phenylpyridine is neurotoxic to the nigrostriatal dopamine pathwayNature, 1986
- Dopaminergic toxicity after the stereotaxic administration of the 1-methyl-4-phenylpyridinium ion (MPP+) to ratsNeuroscience Letters, 1985
- 1-methyl-4-phenylpyridine (MPP+) is toxic to mesencephalic dopamine neurons in cultureNeuroscience Letters, 1985
- Intraneuronal generation of a pyridinium metabolite may cause drug-induced parkinsonismNature, 1984
- Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog SynthesisScience, 1983