Oxygen derived free radicals and the course of Eimeria vermiformis infection in inbred strains of mice
- 1 November 1990
- journal article
- research article
- Published by Wiley in Parasite Immunology
- Vol. 12 (6) , 623-631
- https://doi.org/10.1111/j.1365-3024.1990.tb00992.x
Abstract
Summary Free radical generation by peritoneal leukocytes from BALB/c and C57BL/6 mice was monitored for 18 days following infection with Eimeria vermiformis. Free radical generation occurred earlier and was quantitatively much greater in resistant BALB/c mice than in susceptible C57BL/6 mice, resistance being indicated by a much lower oocyst production and a shorter patent period of E. vermiformis. Plasma greatly enhanced free radical generation in response to a soluble antigen prepared from sporulated oocysts indicating the presence of plasma‐borne factor(s) which enhance free radical generation in response to E. vermiformis.Keywords
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