Studies of anti‐f(ab')2 antibodies and possible immunologic control mechanisms in systemic lupus erythematosus
- 1 December 1984
- journal article
- research article
- Published by Wiley in Arthritis & Rheumatism
- Vol. 27 (12) , 1387-1396
- https://doi.org/10.1002/art.1780271209
Abstract
Studies of anti‐DNA and anti‐F(ab')2 antibodies were performed by enzyme‐linked immunosorbent assay in 51 patients with systemic lupus erythematosus (SLE). Patients with severe, uncontrolled disease showed high levels of anti‐DNA and low levels of anti‐F(ab')2 antibodies. Patients with quiescent SLE usually showed high levels of anti‐F(ab')2 and low levels of anti‐DNA antibodies. Isolated anti‐F(ab')2 antibodies from autologous SLE remission serum or from the sera of unaffected siblings of SLE patients showed maximum inhibition in test systems using affinity‐purified SLE anti‐DNA antibodies reacting with single‐stranded DNA.This publication has 34 references indexed in Scilit:
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