Outcome measurement in osteoarthritis clinical trials: The case for standardisation
- 1 September 1984
- journal article
- Published by Springer Nature in Clinical Rheumatology
- Vol. 3 (3) , 293-303
- https://doi.org/10.1007/bf02032334
Abstract
Outcome measures for clinical trials to be valid and reliable should also be responsive to change. There are currently no standardised methods of measuring the outcome in osteoarthritis clinical trials. A review of 63 trials of nonsteroidal anti-inflammatory drugs revealed a large degree of variability in the items, instruments and scales employed. The implications of this variability are discussed and methods proposed for rationalising outcome measurement in this area of clinical research.Keywords
This publication has 91 references indexed in Scilit:
- Measurement of patient outcome in arthritisArthritis & Rheumatism, 1980
- Indoprofen, a new non-steroidal anti-inflammatory drug, in the treatment of osteoarthrosis: report on a multi-centre study in 1629 patientsCurrent Medical Research and Opinion, 1979
- Naproxen in osteoarthrosis. Double-blind crossover trial.Annals of the Rheumatic Diseases, 1978
- Sulindac. Trials of a new anti-inflammatory drug.Annals of the Rheumatic Diseases, 1978
- Inter-observer reliability of a functional status assessment instrumentJournal of Chronic Diseases, 1978
- KETOPROFEN IN THE MANAGEMENT OF OSTEOARTHROSIS OF THE HIP: COMPARISON WITH PHENYLBUTAZONERheumatology, 1974
- Evaluation Of A Functional Index In Rheumatoid ArthritisScandinavian Journal of Rheumatology, 1973
- Ibuprofen in the treatment of rheumatoid arthritis and osteo-arthritis.Annals of the Rheumatic Diseases, 1967
- Studies of Illness in the AgedJAMA, 1963
- QUANTITATION OF THE MANIFESTATIONS OF RHEUMATOID ARTHRITISThe Lancet Healthy Longevity, 1958