Oral manifestations of chronic graft-v-host disease

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Abstract
Patients (60) were studied 180-500 days after allogeneic marrow transplantation to determine if late oral abnormalities were associated with the presence of chronic graft-vs.-host disease (GVHD). Lip and intraoral mucosal surfaces were evaluated for color, keratinization, atrophy and erythema. Subjective complaints of oral pain and xerostomia were also recorded. Abnormalities were scored on a scale of 0-3 and tested for association with GVHD by .chi.2 test. Oral manifestations most strongly associated with chronic GVHD included atrophy and erythema or lichenoid lesions of the buccal and labial mucosa and oral pain. Oral manifestations resembled several naturally occurring autoimmune disorders. Recognition of these changes can aid in the clinical diagnosis and assessement of established chronic GVHD.