The action of sulphur-containing amino-acids and proteins on liver fat deposition

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Abstract
A greatly increased fat deposition in the liver of the rat is caused by the daily addition of 4 mg. of cystine to diets low in caseinogen and high in fat: increase of cystine has no further effect. The cystine effect is progressively decreased at all levels of dietary caseinogen up to 25%: it is prevented by its 1.8 mg. choline per day. The increased fat deposition caused by cystine increases with time up to 21 days. The cystine effect is not observed when the caseinogen is replaced by albumin. The diets used had no effect on blood fat. Methionine progressively decreases liver fat deposition on an 8% caseinogen diet until the amt. is 0.20% of the diet. At its optimum, methionine is one-fifth as active as choline. S-Methylcysteine and taurine are without effect on liver fat deposition; homocystine acts qualitatively like cystine.