Down's Syndrome

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Abstract
Although the presence of a small extra acrocentric chromosome in Down's syndrome was described more than a decade ago, we have little reliable information on how the chromosomal imbalance produces multiple physical and chemical changes described in the syndrome. In this paper, we will critically review the many reports on the enzyme changes found in Down's syndrome, the studies on the production of DNA and RNA following phytohemagglutinin stimulation of lymphocytes, and the possibilities that Down's syndrome may represent the end result of the action of a susceptibility gene in the mother which would alter the balance between Australia antigen, hepatitis, and leukemia.