Failure of amyotrophic lateral sclerosis to respond to intrathecal steroid and vitamin B 12 therapy

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Abstract
Experimental therapy of amyotrophic lateral sclerosis was started in 26 patients. This treatment consisted of 4 intrathecal injections per month of vitamin B12, 1000 mg., and water-soluble hydrocortisone, 50 mg. Of the patients, 21 received 16 or more such injections. Of the 21 patients, 18 became more severely affected or died, while 2 patients remained unchanged and 1 person improved slightly. The improvement in the latter patient was short-lived, and the patient''s disease progressed again by the 12th month. This investigative project is reported to show the failure of another therapy for amyotrophic lateral sclerosis, the methods used in selecting patients and evaluating the effect of therapy, and, incidentally, the absence of any significant clinical complications of intrathecal injections of vitamin B12 and water-soluble hydrocortisone.

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