Insulin Binding to Cultured Human Fibroblasts Increases with Normal and Precocious Aging
- 30 July 1976
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 193 (4251) , 412-415
- https://doi.org/10.1126/science.180604
Abstract
Specific and nonspecific [125I]insulin binding and concentration of unlabeled hormone producing 50 percent competition with 1.0 nanomolar [125I]insulin for specific binding sites correlated positively with age of fibroblast donors. Cells from four children with precocious aging--three with progeria and one with Rothmund syndrome-resembled those from the chronologically old.This publication has 30 references indexed in Scilit:
- The limited in vitro lifetime of human diploid cell strainsPublished by Elsevier ,2004
- Decreased Insulin Binding to Lymphocytes from Diabetic SubjectsJournal of Clinical Investigation, 1974
- Membrane ReceptorsAnnual Review of Biochemistry, 1974
- Insulin interactions with its receptors: Experimental evidence for negative cooperativityBiochemical and Biophysical Research Communications, 1973
- Absence of Detectable HL—A Antigens on Cultured Fibroblasts in ProgeriaJournal of Clinical Investigation, 1973
- Altered Enzymes in Ageing Human FibroblastsNature, 1972
- The Hutchinson-Gilford progeria syndromeThe Journal of Pediatrics, 1972
- Progeria: a cell culture study on agingJournal of Clinical Investigation, 1971
- Progeria of Hutchinson-Gilford: A caricature of agingAmerican Heart Journal, 1971
- Sleep characteristics and endocrine response in progeriaThe Journal of Pediatrics, 1970