Δ 9 -Tetrahydrocannabinol: Aversive Effects in Rat at High Doses
- 25 February 1972
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 175 (4024) , 911-912
- https://doi.org/10.1126/science.175.4024.911
Abstract
Water-deprived rats were administered a single dose of Δ9-tetrahydrocannabinol either orally or intraperitoneally immediately after their first taste of a saccharine solution. In tests beginning 47 hours after drug administration, a dose-related reversal of rats' normal preference for saccharine was found. The data suggest that the drug produces aversive effects at doses of 1 to 32 milligrams per kilogram.Keywords
This publication has 11 references indexed in Scilit:
- Inhibition of Normal Growth by Chronic Administration of Δ 9 -TetrahydrocannabinolScience, 1971
- Electroencephalographic and Behavioral Alterations Produced by Δ 1 -TetrahydrocannabinolScience, 1971
- Hunger and appetite after single doses of marihuana, alcohol, and dextroamphetamineClinical Pharmacology & Therapeutics, 1971
- Chemical Basis of Hashish ActivityScience, 1970
- l - Δ 9 - trans -Tetrahydrocannabinol in Pigeons: Tolerance to the Behavioral EffectsScience, 1970
- Psychological Effects of TetrahydrocannabinolArchives of General Psychiatry, 1970
- Behavioral Effects in Monkeys of Racemates of Two Biologically Active Marijuana ConstituentsScience, 1968
- Aversion to sucrose produced by contingent x-irradiation: Temporal and dosage parameters.Journal of Comparative and Physiological Psychology, 1968
- Association of Illness with Prior Ingestion of Novel FoodsScience, 1967
- Learning with prolonged delay of reinforcementPsychonomic Science, 1966